China Top Peptide Manufacturer Niche Cosmetic Snap-8 Anti-Wrinkles Free Sample Description:
Detailed Product Information
INCI Name: Acetyl Glutamyl Heptapeptide-1
CAS No.: 868844-74-0
Molecular weight: 1075.18 g/mol
Sequence : Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Type of Ingredient: Peptide
Appearance:Viscous liquid/ White freeze-dried powder
Standard Packing :1L, 25L, 1g,100g
Shelf Life :2 years
The synthesis of SNAP-8 involves a final freeze-drying step. Freeze-dried products are commonly obtained as a polymorphous crystalline powder, which means that locally some aggregates and differences in crystal size may appear. This polymorphism is not associated to chemical differences and extensive work performed by the analytical department has ensured the homogeneity of the product. SNAP-8 is presented either as SNAP-8 Powder, an octapeptide in powder form which can be easily dissolved in water, or as SNAP-8 Solution, an aqueous solution containing 0.5 g/L of the powder version. It can be incorporated at the final stage of the manufacturing product, provided the temperature is below 40 degrees Celsius. Taking into consideration the concentration of peptide in SNAP-8 Solution, it is recommended that 3 to 10% of the solution is present in the final formulation in order to obtain significant anti-wrinkle activity.
What is Snap-8?
Acetyl Glutamyl Heptapeptide-3 or Acetyl Octapeptide-1 (or -3) (SNAP-8) is scientifically and reasonablely designed of anti-wrinkle active ingredients of polypeptide. It has a similar role to Areginine Essence and has become one of the most popular raw materials around the world for upscale anti-wrinkle cosmetics.Anti-wrinkles caused by the contraction of muscles of facial expression, decreasing neuronal excitability by SNARE complex destabilisation.
Snap-8, this ingredient contains eight amino acids and (hence the "Octa") has the same (some say much better) anti wrinkle qualities of Argireline. Snap-8 produced roughly 35% reduction in wrinkle depth.
Snap-8 peptide solution contains an anti-wrinkle octapeptide that is an elongation of the hexapeptide ARGIRELINE peptide. Therefore, it reduces expression wrinkles through a Botu-linum Toxine-like mechanism of action.
The Benefits of SNAP-8
- Reduces the depth of wrinkles on the face caused by the contraction of muscles of facial expression, especially in the forehead and around the eyes.
- A safer, cheaper, and milder alternative to Botu-linum Toxine, topically targeting the same wrinkle-formation mechanism in a very different way.
- Has been incorporated in cosmetic formulations such as emulsions, gels, sera, etc., where removal of the deep lines or wrinkles in the forehead or around the eyes area is desired.
Anti-wrinkle Activity Units (AAUs)
One of the problem of working with peptides with similar effects but different potency is to compare their activities. Several catecholamine release tests at different concentrations of peptides were performed, in order to plot the dose response curves needed to calculate the IC50 values for the different peptides. We can therefore quantity and compare the exocytosis blocking activity, which is directly related to the anti wrinkle power. The IV50 is the 50% inhibitory concentration, in this case, the concentration of active that inhibits 50% of catecholamine secretion. The lower IC50, the smaller the amount needed to inhibit secretion 50%, and the more active the compound is. This facilitates the definition of an anti wrinkle activity unit .
AAU sample = [IC50] esup e/ [IC50] sample
|BoNT A||0.0260 uM||12|
|ESUP E||0.0260 uM||12|