Author: National Institute of Quantum Science and Technology October 26, 2021
A Japanese study showed that the consumption of amino LP7 is a specific combination of essential amino acids that can inhibit the development of dementia.
As we all know, protein intake is essential for maintaining the brain function of the elderly. Now, researchers use mouse models of Alzheimer's disease to show that the intake of a specific group of amino acids can inhibit the death of brain cells, protect the connections between them, reduce inflammation, and protect brain function. Their research shows that this combination of amino acids called Amino LP7 can hinder the development of dementia, including Alzheimer's disease.
Dementia-a condition involving extreme loss of cognitive function-is caused by a variety of diseases, including Alzheimer's disease. According to estimates by the World Health Organization, about 10 million people worldwide suffer from dementia each year, which shows that this disease has a great psychological and social impact. Dementia mainly affects the elderly, and so far, simple and effective strategies to prevent this disease are still elusive.
In a recent study published in Science Advances, Japanese researchers showed that a low-protein diet can accelerate brain degeneration in a mouse model of Alzheimer's disease. More importantly, they found that amino LP7-a supplement containing seven specific amino acids-can slow the development of brain degeneration and dementia in these animals. Their work expands on previous studies that have demonstrated the effectiveness of Amino LP7 in improving cognitive function.
Brain atrophy occurs in a mouse model of Alzheimer's disease, a low-protein diet will accelerate this phenomenon, and amino LP7 will inhibit this situation. The arrow indicates the ventricle, which is observed to increase as the brain shrinks. Image source: National Institute of Quantum Science and Technology
Dr. Makoto Higuchi from the National Institute of Quantum Science and Technology was one of the chief scientists of the study. He explained: “In the elderly, a low-protein diet is related to poor maintenance of brain function. Amino acids are a component of protein. Therefore, , We want to understand whether supplementing with essential amino acids can protect the brains of the elderly from dementia, and if so, what mechanisms will contribute to this protection."
First, the researchers studied how a low-protein diet affects the brain in a mouse model of Alzheimer's disease, which usually indicates the presence of neurodegeneration and abnormal protein aggregates in the brain, called "Tau" aggregates. They found that mice on a low-protein diet not only showed accelerated brain degeneration, but also showed signs of poor neuronal connections. Interestingly, these effects were reversed after amino LP7 supplementation, indicating that the combination of seven specific amino acids can inhibit brain damage.
Next, the research team studied how the amino group LP7 affects different signs of brain degeneration in Alzheimer's disease models. Untreated mice showed high levels of progressive brain degeneration, but amino LP7 treatment suppressed neuronal death, thereby reducing brain degeneration, even though Tau aggregates were still present. Dr. Akihiko Kitamura, who led the research, said: “Tau plaques in the brain are characteristic of Alzheimer’s disease, and most treatments are for them. However, we have shown that this can be overcome by supplementing with amino LP7. Tau deposits and prevents brain atrophy."
Next, in order to understand how Amino LP7 protects the brain, the researchers comprehensively analyzed the changes in gene levels induced by Amino LP7. Their findings are very encouraging. They observed that amino LP7 can reduce brain inflammation and prevent the inflammation-inducing agent kynurenine from entering the brain, thereby preventing inflammatory immune cells from attacking neurons. They also found that Amino LP7 can reduce neuronal death and improve neuronal connections, thereby improving brain function.
"These results show that essential amino acids can help maintain brain balance and prevent brain degeneration. Our research reports for the first time that certain amino acids hinder the development of dementia," said Dr. Hideaki Sato and Dr. Yuhei Takado, both of whom contributed to this research. Made a major contribution. "Although our research was conducted in mice, it brings hope that amino acid intake can also change the development of human dementia, including Alzheimer's disease," they added.
The research team’s research has opened up several ways to better understand how dementia occurs and how to prevent them. Given that amino LP7 can improve the brain function of elderly people without cognitive impairment, their research results indicate that it may also be effective for people with cognitive impairment.
In fact, this patent-pending supplement could one day help millions of people around the world lead an improved, dementia-free life.
Reference: "In a mouse model of tau protein disease, the neurodegenerative process is accelerated by protein malnutrition and slowed by essential amino acids" Authors: Hideaki Sato, Yuhei Takado, Sakiko Toyoda, Masako Tsukamoto-Yasui, Keiichiro Minatohara, Hiroyuki Takuwa, Takuyaa Urushihata, Manami Takahashi, Masafumi, Maiko Ono, Jun Maeda, Akira Orihara, Naruhiko Sabara, Kazuo Aoki, Yukiyo Sorakawa, Mongki Isokawa, Noriko Kawasaki, Mika Kawasaki, Satoko Ueno , Kanda Maka, Nishimura Mai, Suzuki Katsuya, Mitsui Akira, Nagao Kenji, Kitamura Akihiko Higuchi, October 22, 2021, scientific progress. DOI: 10.1126/sciadv.abd5046
The current work is supported by the Young Scientist Grant (20 K15910 to KM)
About Japan's National Institute of Quantum Science and Technology
The National Institute of Quantum Science and Technology (QST) was established in April 2016 to comprehensively and comprehensively promote the development of quantum science and technology. The new organization was formed by the merger of the National Institute of Radiological Sciences (NIRS) with certain businesses previously undertaken by the Japan Atomic Energy Agency (JAEA).
The mission of QST is to improve the level of quantum and radiology science and technology by devoting itself to the research and development of quantum science and technology, the impact of radiation on humans, radiation emergency medicine and the medical use of radiation.
To ensure that R&D has a significant academic, social and economic impact, and maximize the benefits from global innovation, QST is working hard to establish a world-leading R&D platform, explore new areas, and serve as a radiation protection and radiation center emergency medicine.
About Dr. Makoto Higuchi, National Institute of Quantum Science and Technology, Japan
Dr. Makoto Higuchi is a well-known neuroscientist and the head of the functional brain imaging department of the National Institute of Quantum Science and Technology in Japan. Received a doctorate degree in 1997. Received a doctorate in medicine from Northeastern University Graduate School of Medicine, and completed postdoctoral training at the University of Pennsylvania School of Medicine. His main research interest lies in translational molecular imaging, which aims to elucidate the pathophysiology of neuropsychiatric diseases such as schizophrenia, depression, and Alzheimer's disease. He was praised for developing reagents for imaging pathological tau protein deposits in neurodegenerative diseases.
This article introduces the content of LP7 in detail: https://www.science.org/doi/10.1126/sciadv.abd5046
And how to obtain this amino acid?
Which seven amino acids are it?
Good news for mice! Essential amino acids? balanced diet. Avoid rubbish. This has all the characteristics of the quack doctor of the 19th century, who dealt with his eccentric warlock behind the carriage. Is hydroxychloroquine used? Chasers with Lasur.
What impressed me was the dosage. LP7 was administered to mice at a dose of 1 g/kg x 2/day. If this is the required beneficial amount, a 50 kg adult must consume 100 grams per day. Based on most commercially available EAA supplements (in powder form), that is, 14 servings, each with approximately 250 ml of water, for a total of 3.5 liters per day. This is a difficult task for a young and healthy adult, but it is almost impossible for an elderly person. Before considering it as a treatment route, I want to see if the results can be repeated with a quarter of that amount.
Why is the amino acid purchasing information not disclosed?
How can I buy Amino LP7.
@JG Crawford When converting mouse doses to humans, you do not convert directly to mass ratios. It will be even less for humans. I don't remember the formula, but it is much smaller than the ratio. I have a protein drink in front of me now. It says 30g is its weight. I suspect this may be on the court.
However, I think this is far from proven effective for humans. The mouse model of Alzheimer's disease has been shown to be very bad in the past. They cured Alzheimer's disease in mice time and time again, but when they applied these treatments to humans, they became boring. Of course, it is still worth reporting. We can hope. If you really want to prevent Alzheimer's disease, the best option is to do more than 20 minutes of aerobic exercise for more than 5 days a week, or a similar number of saunas to make your heart beat at the same high speed. Add good nutrition, especially omega 3 and supplements to reduce inflammation and regular social activities, and you have a reasonable chance to avoid it. If you want more assurance, exercise every day instead of 5 days a week.
Then there are a lot of speculative things that might help. Completely resolve any sleep apnea problems and ensure that regular sleep all night is reasonable. HEPA air filtration in the home may be beneficial (but not ionic substances). There is evidence that black metal nanoparticles in the air may be related to this. In any case, clean air should be harmless and quite cheap.
Then came the very speculative and usually expensive or unpleasant attempts: using plasma removers to remove toxins from the blood (which seems to have great benefits for aging mice, but not a cheap procedure), hyperbaric oxygen therapy (expensive , But it seems to be beneficial) This time in real humans... But these benefits may or may not include brain health), this kind of simulated fasting diet, several times a year you consume about the usual calories 1/3, but the calorie intake as protein is less than 10% for a few days...usually 4 or 5 days. This should lower IGF-1, remove some senescent cells, and allow the body and cells to remove waste and perform other cleaning tasks. It can also stimulate neuron growth. But this state is temporary. You hope that your diet will return to normal in a few days, and you want to maintain this slightly repaired state. Obviously, not everyone is healthy enough to fast/close to fasting. My last one is a low advanced glycation end products (AGEs) diet. These AGEs are dangerous cross-links and are associated with many aging diseases, including Alzheimer's disease. Minimizing these is a bit challenging. They are made when food is cooked at high temperatures, mixed and fermented at high speeds. Some foods are naturally high in content. Pine nuts are one of them. AGEs are unavoidable, so it depends on how much you want to reduce them. It is easy to avoid the most serious foods: fried meat, roasted meat, roasted meat and processed meat, butter, margarine, mayonnaise, hard cheese, cream cheese roasted nuts, roasted/roasted oil, nut butters using roasted nuts, peanut oil, cottonseed Oil, believe it or not, olive oil and canola oil. If you want to make the smallest changes, you can choose: bacon, butter, margarine, mayonnaise, hot dogs, toasted sesame oil, parmesan cheese, American white cheese, fried chicken, and pine nuts. And use avocado oil and sunflower oil. Use earthen pots, pressure cookers and steamers more often. Eat more soups, stews, and peppers. Some supplements and drugs can also reduce the formation of AGEs in the body. Most of them are antioxidants, but metformin and aspirin can also reduce AGEs.
There is nothing new here. A balanced diet, exercise, sleep and clean water, and a positive perspective. Here, they are just discussing the creativity of the laboratory, putting together a few amino groups and creating a theory that serves them.
This may be a scam. ! ! ! 🤔
I just lost my husband for two weeks late
The biggest idiot award here goes to John Carcalis! There are other celebrities, including Rose Jane and Libby. If you are not in the health field, it is best not to make some uneducated comments to yourself...
Yes, what are the specific amino acids? I don't know about dementia, but I am a 70-year-old man who only started strength training 6 years ago. I take powder containing Leucine, Isoleucine, Value and Lysine to help me gain and protect muscles. At least they worked very well for me. I am the strongest and strongest in my life. I also think it's great
First of all, I really want to have an impact on humans. If we can find these methods, then its loyal fans. The absence of dangerous molecules or invasive procedures certainly sounds good. Looking forward to more data.
Next, for those looking for amino groups, please click on the research link and get the supplementary PDF, which has a table that can show you detailed information about the percentage of each amino acid in what they call LP7.
Taking the recommended amino acids will not harm you, especially considering that they are essential; unless you have conditions to prevent it, such as phenylalanine, and pay attention to the goods you buy and other ingredients that may be contained in them; for example Caffeine or other molecules that may be bad for "you" or prevent you from adjusting the dosage correctly; read the label and ingredients. I am not a doctor, and I do not recommend that you take or not take any form of substances, including these amino groups. I can tell you that AZ is not friendly to my family and is the driving force of my interest.
Everything must be moderate, not excessive. If you choose to take them, you should be able to find safe dose data for each through a reputable health site. For me and others, it is difficult to get a certain amount of specific nutrients without a little supplement; be careful and make sure you get what you want, not something else, or mainly something else.
You can get the form from the PDF and order the details from GNC or Vitamin Store, or choose your own location. I have seen from some quick searches that you can find most isolated or a good subset. Then you need to mix and match powders or pills to get the correct percentage and adjust the total amount based on your diet and target weight. But always keep in mind that if the product you buy contains other substances, such as vitamins, etc., you should not over-eat them, then your ability to safely adjust your intake to obtain the correct percentage will be limited.
Remember that even too much water can be fatal, so please always think!
Considering that we are humans, not mice, and that the prevalence of neurodegenerative diseases is high among people who consume a lot of protein. This is meaningless.
Where do I buy this product... What brand has this product, please tell me. Thank you.
View fulvic acid minerals.
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