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L-Arginine is involved in many different biological processes. Recent reports indicate that it may also be involved in the 2019 Coronavirus Disease (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Play a key role in the Here, we provide an updated systematic overview of the current evidence for the functional contribution of L-arginine in COVID-19, describe its effects on endothelial cells and the immune system, and discuss its potential as a therapeutic tool, These all come from recent clinical trials.