Wu Aijie, wait. obesity. 2021; doi: 10.1002/by.23261.
Wu Aijie, wait. obesity. 2021; doi: 10.1002/by.23261.
According to the results of the study published in Obesity, the cardiometabolic health indicators of adolescents with increased central obesity during childhood may deteriorate.
According to Allison Wu, MD, a physician in pediatric gastroenterology and nutrition, in the data of 620 children from the Viva project, from mid-childhood to early adolescence, central obesity measured by waist circumference and DXA increased more and worsened. The cardiometabolic characteristics are related to the Boston Children's Hospital.
"The increase in obesity through the waist monitoring center may provide additional information to supplement existing BMI measures to identify children with higher cardiometabolic risk," Wu told Healio.
Wu and colleagues obtained data from Project Viva, an ongoing prospective cohort study in which women were recruited during prenatal care. The researchers obtained data on 620 children who participated in the follow-up of middle childhood (average age 7.8 years) and early adolescence (average age 12.9 years), and recorded at least one indirect and direct cardiac metabolism during the two follow-ups. Central obesity measurement. The result of the measurement. Waist circumference is used to measure indirect obesity, and a DXA scan is performed to measure direct obesity. Systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, alanine aminotransferase, insulin resistance homeostasis model assessment (HOMA-IR), high-sensitivity C-reactive protein, leptin, and adiponectin are used as cardiometabolic markers .
From mid-childhood to early adolescence, participants’ waist circumference increased by an average of 2.6 cm per year, visceral adipose tissue increased by 2.7 square centimeters per year, subcutaneous abdominal adipose tissue increased by 11.5 square centimeters per year, and trunk fat increased by 0.7 kg per year.
After adjusting for covariates and changes in total obesity and height, each standard deviation increase in waist circumference was correlated with a higher log triglyceride (β = 0.07 mg/dL; 95% CI, 0.02-0.13), log HOMA- IR (β = 0.15 U; 95% CI, 0.08-0.23), logarithmic alanine aminotransferase (β = 0.07 U/L; 95% CI, 0.03-0.12), logarithmic high sensitivity C-reactive protein (β = 0.43 mg/L; 95% CI, 0.28-0.58) and log leptin (β = 0.35 ng/mL; 95% CI, 0.27-0.43). The increase in waist circumference is also associated with lower log adiponectin (β = –0.09 mg/dL; 95% CI, –0.15 to –0.03).
All three indicators of direct central obesity are associated with a higher systolic z-score in early adolescence. In addition, each increase in standard deviation of subcutaneous abdominal adipose tissue was correlated with higher log HOMA-IR (β = 0.12 U; 95% CI, 0.01-0.22) and log alanine aminotransferase (β = 0.11 U/L) ; 95% CI, 0.05 -0.18) and lower log HDL cholesterol (β = –0.06 mg/dL; 95% CI, –0.11 to –0.02). Higher trunk fat is also associated with increased log HOMA-IR (β = 0.18 U; 95% CI, 0.07-0.29) and log alanine aminotransferase (β = 0.09 U/L; 95% CI, 0.02-0.16) and Low log HDL-related cholesterol (β = –0.07 mg/dL; 95% CI, –0.12 to –0.02).
"When comparing direct and indirect measures of central obesity increases, there is no single measure that can prove the best predictive value for most cardiometabolic health outcomes," Wu said.
Allison Wu, MD, can be contacted at allison.wu@childrens.harvard.edu.
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