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Partnership will expand patient access to Endari®

Torrance, California, November 11, 2021/PRNewswire/ - Emmaus Life Sciences, Inc. (OTC: EMMA) is a commercial-stage biopharmaceutical company that is also in the field of sickle cell disease treatment The leader of the company today announced a partnership with UpScript IP Holdings, a limited liability company. (UpScript), provides telemedicine solutions for patients with sickle cell disease and expands the use of Endari®, Emmaus' prescription L-glutamine oral powder for the treatment of sickle cell disease.

The telemedicine cooperation with UpScript will allow patients to seek medical treatment without leaving home, thereby eliminating the risk of infection that may occur during the visit. Other benefits for patients include being able to obtain Endari’s doctor’s authorization and prescription on the same day, and deliver the prescription directly to their home in just a few days.

"This partnership with UpScript is a proven, direct-to-consumer telemedicine platform that provides us with another key way through which we can meaningfully improve sickle cell patients’ access to Endari. "Doctor of Medicine, Master of Public Health, Chairman and CEO Yutaka Niihara said Emmaus. "Endari aims to reduce the acute complications of sickle cell disease in adults and pediatric patients aged 5 years and older, and is recognized as an important tool for the treatment of this debilitating disease. It is convenient and does not require preliminary or follow-up blood test monitoring. Endari has It is well tolerated and can be easily consumed with water, juice or other liquids. We are proud to work with UpScript and believe that Endari may become the first choice for the treatment of sickle cell disease patients in a telemedicine environment."

George Sekulich, Senior Vice President of Global Commercialization at Emmaus, added: "Once deployed, our telemedicine service will provide patients with a new and convenient way to receive Endari and improve their overall experience. We plan to do so in the coming months. Launch this key service within."

Peter Ax, CEO and founder of UpScript, said: “UpScript looks forward to launching this partnership and improving Endari’s access to sickle cell disease patients. “Our direct-to-consumer platform enables pharmaceutical companies to facilitate, Reach patients in a safe and effective way, and improve the lives of patients by making medicines more accessible and affordable. "

About Emmaus Life Sciences Emmaus Life Sciences, Inc. is a commercial-stage biopharmaceutical company and a leader in the treatment of sickle cell disease. The company currently sells Endari® (L-glutamine oral powder) approved by the U.S. Food and Drug Administration to reduce acute complications of sickle cell disease in adults and children 5 years and older. The company is also committed to discovering and developing innovative therapies and therapies for certain rare and orphan diseases and diseases that affect larger populations (such as diverticulosis). For more information, please visit www.emmausmedical.com.

About UpScript UpScript provides pharmaceutical companies and consumer product companies with a direct-to-consumer telemedicine platform that can easily obtain high-quality healthcare services. In 2002, we became the first company in the United States to obtain permission to prescribe on the Internet through online physician consultation. Since then, we have served more than one million consumers in all fifty states. Learn more on www.UpScriptHealth.com.

About Endari® (prescription grade L-glutamine oral powder) Endari® is Emmaus' prescription grade L-glutamine oral powder, which was approved by the FDA in July 2017 for the treatment of sickle in adults and children aged 5 years and older Shape cell disease. Endari® began to be sold in the United States in 2018.

Indications Endari® is used to reduce acute complications of sickle cell disease in adults and children aged 5 years and older.

Important safety information The most common adverse reactions in clinical studies (incidence> 10%) are constipation, nausea, headache, abdominal pain, cough, limb pain, back pain, and chest pain.

Adverse reactions leading to treatment interruption included 1 case each of hypersplenism, abdominal pain, indigestion, burning sensation and hot flashes.

The safety and effectiveness of Endari in pediatric patients with sickle cell disease under 5 years of age have not been established.

For more information, see Endari's full prescribing information: www.ENDARIrx.com/PI.

About sickle cell disease There are approximately 100,000 people with sickle cell disease (SCD) in the United States and millions of people worldwide. The sickle gene exists in every ethnic group, not just among people of African descent. In the United States, it is estimated that one in 365 African Americans and 16,300 Hispanic Americans was born with SCD. 1 The genetic mutation that causes SCD causes an individual's red blood cells to deform into a "C" or sickle shape, reducing their ability to transport oxygen throughout the body. These sickle red blood cells decompose rapidly, become very viscous, and have a tendency to clump together, causing them to get stuck in blood vessels and cause damage. The result is reduced blood flow to remote organs, which can lead to physical symptoms such as pain, tissue and organ damage, and premature death. 2

1 Source: data and statistics on sickle cell disease-National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, December 2020. 2 Source: Committee on Addressing Sickle Cell Disease-Strategic Plan and Blueprint for Action-National Academy of Sciences Press, 2020.

Forward-Looking Statements This press release contains forward-looking statements made under the safe harbor provisions of the Private Securities Litigation Reform Act of 1995 (as amended), including statements regarding the possible increase in access to Endari through telemedicine. These forward-looking statements are subject to many time-varying assumptions, risks and uncertainties, including risks inherent in the regulatory approval process and other previously disclosed in the company’s annual report on Form 10-K/A to the US Securities and Exchange Commission. The actual results of the SEC's report issued on August 10, 2021 and our quarterly report on Form 10-Q may differ materially. Such forward-looking statements are only effective on the date they are made, and Emmaus assumes no obligation to update them, unless required by law.

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Source: Emmaus Life Sciences, Inc.

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