|Synonyms:||D-(+)-SERINE;D-SERINE;D-2-AMINO-3-HYDROXYPROPIONIC ACID;D-2-AMINO-3-HYDROXYPROPANOIC ACID;D-BETA-HYDROXYALANINE;H-D-SER-OH;2-AMINO-3-HYDROXYPROPANOIC ACID;(R)-2-AMINO-3-HYDROXYPROPIONIC ACID|
|Product Categories:||Amino Acid Derivatives;Serine [Ser, S];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acids;Glutamate receptor;Glutamate;Amines;Inhibitors;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Pharmaceutical intermediates;D-Cycloserine intermediate;Lacosamide intermediate|
DSerine, synthesized in the brain by serine racemase from Lserine (its enantiomer), serves as both a neurotransmitter and a gliotransmitter by activating NMDA receptors, making them able to open if they then also bind glutamate.
Dserine is a potent agonist at the glycine site of the NMDAtype glutamate receptor. For the receptor to open, glutamate and either glycine or Dserine must bind to it. In fact, Dserine is a more potent agonist at the glycine site on the NMDAR than glycine itself. Dserine was only thought to exist in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of Daspartate.
Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor to several amino acids including glycine and cysteine, and tryptophan in bacteria. It is also the precursor to numerous of other metabolites, including sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis. Serine dehydratase is an enzyme that converts serine to pyruvate.
It is used as a nutrient for amino acids in medicine.
White crystals or crystalline powder
State of solution
Heavy metals, as Pb
Loss on drying
Residue on ignition